If you have tried it what were your results?
Anybody tried to run NAV 2009 R2 on Windows Server 2016?
Which again doesn’t mean that it doesn’t work. [:)]
It just means Microsoft didn’t test a version they don’t support anymore.
If for production environment then if it was me, then I would stick to the most recent supported version. Even if it did work in a test environment.
I have not tried it. But if you do try, then at least keep the database version to one of the supported versions.