ODBC with VPN

Hello, Is it possible to use ODBC with a VPN connection. The problem is that we have a client with an access database. They send it every day to their clients, which use the access database with ODBC to get the information on their system. Now we have changed the access database with navision, which will be consulted by VPN. But the only problem is that they need their data form them system. So is it possible to use ODBC with VPN ? Thx Steve