Hola Aitor,
Yes, it will be better change everything to RunOnClient=No. This way, you only need to install (if necessary) DotNet components in one computer (server) and will work on every client… of course, can exist some exeptions (but is not the case with XML DotNet vars) that require RunOnClient=True. I think that if DotNet var RunOnClient is defined as Yes, you can only use it in Windows Client (it doesn’t work in web client nor phone/tablet client), but I’m not shure.